TRPS1 MODULATES CHROMATIN ACCESSIBILITY TO REGULATE ESTROGEN RECEPTOR ALPHA (ER) BINDING AND ER TARGET GENE EXPRESSION IN LUMINAL BREAST CANCER CELLS.

Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout.We introduced an inducible degron tag into the native TRPS1 locus within a luminal breast cancer cell line to identify the direct target

The aim of this study Console Base was to design and evaluate the properties of solid dispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) as the hydrophilic copyright.These binary solid dispersions were prepared at varying drug loadings using the solvent evaporation method.The samples were evaluated for their in vitro dissolut